Hi Martin,
First of all, note 8963 says: "Processing time = response time".
And Performance Analysis in SAP is a very very big area.
I'm more interested in this figure: Sequential reads 378.211 Direct Reads 26.690
Mainly, Direct Read refers to accesses in which a maximum of one line is returned by the database, otherwise Sequential Read refers to all other read database accesses, in which there may be more than one line returned.
In case of Sequential Read, when you perform a trace on these queries you will see that index is used in most cases. However Direct Read have better performance than Sequential.
So my idea is to check what the job really does, which tables are being read sequentially (SM50 while the job is running), and which SQL statements might be expensive (ST05, execution plan).
Then you can check if those tables are being read using indexes (if not, maybe create new index), also check if the daily update statistics of your database is running (SM13), also check if buffers are not "red" (ST02), and maybe have an ABAP-er recheck the SQL-statements to optimize them.
It could also helpful to check the database area (parameters) as well, but you need to check the figures on ST04 to be able to analyze this.
So again, this is only my tips to check with the info you are providing, and not all conclusive by any means.
I hope this will help you.
Regards,
Andre